Abnormal pupil light reflex after Fluralaner (Bravecto) in dogs

76 reports to the FDA describe abnormal pupil light reflex in dogs given Fluralaner. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

76Reports
100%Marked serious
33%Recovered
28%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
9 20%
1–2 days
11 24%
3–7 days
5 11%
1–4 weeks
9 20%
Over a month
11 24%

How the animals did

Recovered
6 7.9%
Recovered with lasting effects
19 25%
Still unwell when reported
22 29%
Died
9 12%
Euthanised
12 16%
Not known
8 11%

Problems reported at the same time

Age of the animals

Under 1 year
11
1–3 years
11
4–7 years
18
8–11 years
23
12+ years
10

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause abnormal pupil light reflex in dogs?
76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal pupil light reflex with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with abnormal pupil light reflex