Tympanic rupture after Florfenicol + Mometasone + Terbinafine in dogs

The FDA has received 98 reports of tympanic rupture in dogs after Florfenicol + Mometasone + Terbinafine. That is 2.8% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

98Reports

92%Marked serious

22%Recovered

2.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

44 49%

1–2 days

18 20%

3–7 days

7 7.8%

1–4 weeks

15 17%

Over a month

6 6.7%

How the animals did

Recovered

20 20%

Recovered with lasting effects

2 2.0%

Still unwell when reported

31 32%

Euthanised

2 2.0%

Not known

43 44%

Problems reported at the same time

Head tilt - ear disorder

36 37%

32 33%

31 32%

23 23%

21 21%

20 20%

Didn't work as expected

20 20%

Ear discharge

20 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Florfenicol + Mometasone + Terbinafine cause tympanic rupture in dogs?: 98 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tympanic rupture with similar medicines

Tympanic rupture after Genta Momet Clotrim 21 reports · 0.9% of its reports
Tympanic rupture after Ketoconazole 20 reports · 0.9% of its reports

All reported side effects of Florfenicol + Mometasone + Terbinafine in dogs · Medicines most reported with tympanic rupture