Ear canal disorder after Florfenicol + Mometasone + Terbinafine in dogs

The FDA has received 53 reports of ear canal disorder in dogs after Florfenicol + Mometasone + Terbinafine. That is 1.5% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

53Reports

66%Marked serious

9.4%Recovered

7.5%Died or euthanised

3 daysTypical onset

How soon it started

Same day

18 37%

1–2 days

6 12%

3–7 days

6 12%

1–4 weeks

15 31%

Over a month

4 8.2%

How the animals did

Recovered

4 7.5%

Recovered with lasting effects

1 1.9%

Still unwell when reported

16 30%

Died

2 3.8%

Euthanised

2 3.8%

Not known

28 53%

Problems reported at the same time

Didn't work as expected

18 34%

Head tilt - ear disorder

14 26%

13 25%

13 25%

12 23%

11 21%

10 19%

10 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Florfenicol + Mometasone + Terbinafine cause ear canal disorder in dogs?: 53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Florfenicol + Mometasone + Terbinafine in dogs · Medicines most reported with ear canal disorder