Pacing after Fipronil + S-methoprene (Frontline Plus) in dogs
The FDA has received 24 reports of pacing in dogs after Fipronil + S-methoprene. That is 0.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.
24Reports
71%Marked serious
50%Recovered
4.2%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause pacing in dogs?
- 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Pacing with similar medicines
- Pacing after Spinosad (Comfortis) 67 reports · 0.1% of its reports
- Pacing after Lufenuron + Milbemycin Oxime (Sentinel) 45 reports · 0.2% of its reports
- Pacing after Imidacloprid + Moxidectin (Advantage Multi) 77 reports · 0.6% of its reports
- Pacing after Nitenpyram (Capstar) 33 reports · 0.3% of its reports
- Pacing after Cyphenothrin + Fipronil + S-methoprene 20 reports · 3.1% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with pacing