Splenomegaly after Famotidine in dogs

26 reports to the FDA describe splenomegaly in dogs given Famotidine. That is 1.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

85%Marked serious

15%Recovered

50%Died or euthanised

16 daysTypical onset

How soon it started

Same day

5 23%

1–2 days

1 4.5%

3–7 days

3 14%

1–4 weeks

5 23%

Over a month

8 36%

How the animals did

Recovered

3 12%

Recovered with lasting effects

1 3.8%

Still unwell when reported

5 19%

Died

4 15%

Euthanised

9 35%

Not known

4 15%

Problems reported at the same time

20 77%

16 62%

16 62%

15 58%

Abnormal ultrasound finding

15 58%

Death

13 50%

Blood problems

10 38%

Abnormal radiograph finding

10 38%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Famotidine cause splenomegaly in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Splenomegaly with similar medicines

Splenomegaly after Cefpodoxime 26 reports · 0.6% of its reports
Splenomegaly after Tramadol 26 reports · 0.7% of its reports

All reported side effects of Famotidine in dogs · Medicines most reported with splenomegaly