Splenomegaly after Cefpodoxime in dogs

The FDA has received 26 reports of splenomegaly in dogs after Cefpodoxime. That is 0.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

73%Marked serious

0.0%Recovered

46%Died or euthanised

30 daysTypical onset

How soon it started

Same day

1 6.7%

1–2 days

0 0.0%

3–7 days

1 6.7%

1–4 weeks

6 40%

Over a month

7 47%

How the animals did

Still unwell when reported

8 31%

Died

5 19%

Euthanised

7 27%

Not known

6 23%

Problems reported at the same time

Liver problems

19 73%

Loss of appetite

17 65%

Lethargy

14 54%

Abnormal radiograph finding

12 46%

12 46%

12 46%

10 38%

8 31%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Cefpodoxime cause splenomegaly in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Splenomegaly with similar medicines

Splenomegaly after Tramadol 26 reports · 0.7% of its reports
Splenomegaly after Famotidine 26 reports · 1.0% of its reports

All reported side effects of Cefpodoxime in dogs · Medicines most reported with splenomegaly