Loss of appetite after Dexamethasone + Neomycin + Polymyxin B in dogs

The FDA has received 31 reports of loss of appetite in dogs after Dexamethasone + Neomycin + Polymyxin B. That is 19% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

31Reports
77%Marked serious
9.7%Recovered
39%Died or euthanised
45 daysTypical onset
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How soon it started

Same day
3 14%
1–2 days
1 4.5%
3–7 days
4 18%
1–4 weeks
1 4.5%
Over a month
13 59%

How the animals did

Recovered
3 9.7%
Still unwell when reported
8 26%
Died
1 3.2%
Euthanised
11 35%
Not known
8 26%

Problems reported at the same time

16 52%
Kidney problems
13 42%
Death
11 35%
Blood problems
7 23%
Hypoalbuminaemia
6 19%
Weight loss
6 19%

Age of the animals

Under 1 year
0
1–3 years
4
4–7 years
8
8–11 years
8
12+ years
10

About this medicine

Dexamethasone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Dexamethasone + Neomycin + Polymyxin B cause loss of appetite in dogs?
31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 45 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Dexamethasone + Neomycin + Polymyxin B in dogs · Medicines most reported with loss of appetite