Application site reaction after Chlorhexidine Digluconate in dogs

The FDA has received 33 reports of application site reaction in dogs after Chlorhexidine Digluconate. That is 34% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

33Reports

0.0%Marked serious

27%Recovered

0.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

17 52%

1–2 days

7 21%

3–7 days

2 6.1%

1–4 weeks

3 9.1%

Over a month

4 12%

How the animals did

Recovered

9 27%

Still unwell when reported

17 52%

Not known

7 21%

Problems reported at the same time

Skin redness

7 21%

Itching

3 9.1%

Hair loss

2 6.1%

Vocalising

1 3.0%

Swelling

1 3.0%

Restlessness or agitation

1 3.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Chlorhexidine Digluconate cause application site reaction in dogs?: 33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

Application site reaction after Melarsomine (Immiticide) 22 reports · 0.1% of its reports
Application site reaction after Diphenhydramine 47 reports · 1.0% of its reports
Application site reaction after Butorphanol 28 reports · 0.6% of its reports
Application site reaction after Cefpodoxime 47 reports · 1.2% of its reports
Application site reaction after Tramadol 23 reports · 0.6% of its reports
Application site reaction after Florfenicol + Mometasone + Terbinafine 104 reports · 2.9% of its reports
Application site reaction after Isoflurane 20 reports · 0.7% of its reports
Application site reaction after Cephalexin 21 reports · 0.8% of its reports
Application site reaction after Famotidine 25 reports · 0.9% of its reports
Application site reaction after Clotrimazole + Gentamicin + Mometasone 42 reports · 1.6% of its reports

All reported side effects of Chlorhexidine Digluconate in dogs · Medicines most reported with application site reaction