Hyponatremia after Carprofen (Rimadyl) in dogs

234 reports to the FDA describe hyponatremia in dogs given Carprofen. That is 0.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

234Reports
33%Marked serious
2.1%Recovered
52%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
13 16%
1–2 days
17 20%
3–7 days
19 23%
1–4 weeks
11 13%
Over a month
23 28%

How the animals did

Recovered
4 1.7%
Recovered with lasting effects
1 0.4%
Still unwell when reported
35 15%
Died
99 42%
Euthanised
22 9.4%
Not known
73 31%

Problems reported at the same time

Age of the animals

Under 1 year
22
1–3 years
25
4–7 years
63
8–11 years
86
12+ years
35

About this medicine

Carprofen relieves pain and inflammation from arthritis or after surgery.

Products with this ingredient include Rimadyl, Novox, Vetprofen. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Carprofen cause hyponatremia in dogs?
234 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyponatremia with similar medicines

All reported side effects of Carprofen in dogs · Medicines most reported with hyponatremia