Skin rash or irritation after Buprenorphine in dogs

The FDA has received 48 reports of skin rash or irritation in dogs after Buprenorphine. That is 3.0% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

48Reports

69%Marked serious

19%Recovered

27%Died or euthanised

9 daysTypical onset

How soon it started

Same day

7 16%

1–2 days

6 14%

3–7 days

7 16%

1–4 weeks

14 33%

Over a month

9 21%

How the animals did

Recovered

8 17%

Recovered with lasting effects

1 2.1%

Still unwell when reported

18 38%

Died

7 15%

Euthanised

6 13%

Not known

8 17%

Problems reported at the same time

18 38%

17 35%

15 31%

14 29%

14 29%

13 27%

13 27%

12 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause skin rash or irritation in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Dexmedetomidine (Dexdomitor) 64 reports · 1.2% of its reports

All reported side effects of Buprenorphine in dogs · Medicines most reported with skin rash or irritation