Milbemycin Oxime + Spinosad (Trifexis) side effects in Great Pyreneess

414 FDA reports involve Milbemycin Oxime + Spinosad in a Great Pyrenees. These are the problems they describe.

Vomiting
212 51%
Didn't prevent heartworm
83 20%
Lethargy
50 12%
Didn't work as expected
37 8.9%
Diarrhea
23 5.6%
Loss of appetite
19 4.6%
Itching
18 4.3%
Drooling
18 4.3%
Death
17 4.1%
Didn't stop fleas
16 3.9%
Didn't stop worms
13 3.1%
Seizures
12 2.9%

All reports for Milbemycin Oxime + Spinosad in dogs