Allergic reaction after Benadryl in dogs

51 reports to the FDA describe allergic reaction in dogs given Benadryl. That is 21% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports
88%Marked serious
22%Recovered
5.9%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
36 75%
1–2 days
4 8.3%
3–7 days
4 8.3%
1–4 weeks
2 4.2%
Over a month
2 4.2%

How the animals did

Recovered
11 22%
Still unwell when reported
35 69%
Died
1 2.0%
Euthanised
2 3.9%
Not known
2 3.9%

Problems reported at the same time

26 51%
18 35%
13 25%
Skin rash or irritation
7 14%
Skin redness
7 14%

Age of the animals

Under 1 year
10
1–3 years
15
4–7 years
16
8–11 years
8
12+ years
1

About this medicine

Type: medicine.

Questions owners ask

Can Benadryl cause allergic reaction in dogs?
51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

All reported side effects of Benadryl in dogs · Medicines most reported with allergic reaction