Urinary tract infection after Velagliflozin (Senvelgo) in cats

The FDA has received 171 reports of urinary tract infection in cats after Velagliflozin. That is 3.6% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported unusually often with this medicine.

171Reports
35%Marked serious
5.8%Recovered
12%Died or euthanised
18 daysTypical onset
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How soon it started

Same day
14 9.3%
1–2 days
21 14%
3–7 days
29 19%
1–4 weeks
22 15%
Over a month
65 43%

How the animals did

Recovered
10 5.8%
Still unwell when reported
34 20%
Died
5 2.9%
Euthanised
15 8.8%
Not known
107 63%

Problems reported at the same time

Weight loss
62 36%
Loss of appetite
57 33%
Ketosis
56 33%
Lethargy
48 28%
Kidney problems
48 28%
Didn't work as expected
40 23%
Ketonuria
34 20%
Vomiting
33 19%

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
13
8–11 years
72
12+ years
80

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause urinary tract infection in cats?
171 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 18 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary tract infection with similar medicines

All reported side effects of Velagliflozin in cats · Medicines most reported with urinary tract infection