Retching after Spinosad (Comfortis) in cats

25 reports to the FDA describe retching in cats given Spinosad. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all cat medicines.

25Reports

16%Marked serious

40%Recovered

8.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

12 60%

1–2 days

1 5.0%

3–7 days

1 5.0%

1–4 weeks

2 10%

Over a month

4 20%

How the animals did

Recovered

7 28%

Recovered with lasting effects

3 12%

Still unwell when reported

2 8.0%

Died

2 8.0%

Not known

11 44%

Problems reported at the same time

21 84%

7 28%

5 20%

3 12%

2 8.0%

2 8.0%

2 8.0%

2 8.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause retching in cats?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Retching with similar medicines

Retching after Imidacloprid + Moxidectin (Advantage Multi) 36 reports · 0.4% of its reports

All reported side effects of Spinosad in cats · Medicines most reported with retching