Liver problems after Selamectin (Revolution) in cats
The FDA has received 386 reports of liver problems in cats after Selamectin. That is 1.8% of all reports for this medicine, compared with 2.8% across reports for all cat medicines, so it is reported less often than average with this medicine.
386Reports
23%Marked serious
5.2%Recovered
27%Died or euthanised
2 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).
Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Selamectin cause liver problems in cats?
- 386 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 2 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Liver problems with similar medicines
- Liver problems after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) 82 reports · 2.5% of its reports
All reported side effects of Selamectin in cats · Medicines most reported with liver problems