Elevated amylase after Selamectin (Revolution) in cats

45 reports to the FDA describe elevated amylase in cats given Selamectin. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all cat medicines, so it is reported less often than average with this medicine.

45Reports

20%Marked serious

2.2%Recovered

18%Died or euthanised

5 daysTypical onset

How soon it started

Same day

5 28%

1–2 days

3 17%

3–7 days

2 11%

1–4 weeks

5 28%

Over a month

3 17%

How the animals did

Recovered

1 2.2%

Still unwell when reported

14 31%

Died

7 16%

Euthanised

1 2.2%

Not known

22 49%

Problems reported at the same time

24 53%

18 40%

17 38%

16 36%

14 31%

11 24%

9 20%

Elevated creatine-kinase (ck)

8 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause elevated amylase in cats?: 45 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Selamectin in cats · Medicines most reported with elevated amylase