Cardiac disorder after Selamectin (Revolution) in cats

22 reports to the FDA describe cardiac disorder in cats given Selamectin. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all cat medicines, so it is reported less often than average with this medicine.

22Reports
32%Marked serious
0.0%Recovered
41%Died or euthanised
–Typical onset
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How the animals did

Still unwell when reported
5 23%
Died
6 27%
Euthanised
3 14%
Not known
8 36%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
5
4–7 years
5
8–11 years
5
12+ years
6

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause cardiac disorder in cats?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Selamectin in cats · Medicines most reported with cardiac disorder