Cardiac arrest after Selamectin (Revolution) in cats

32 reports to the FDA describe cardiac arrest in cats given Selamectin. That is 0.1% of all reports for this medicine, compared with 0.8% across reports for all cat medicines, so it is reported less often than average with this medicine.

32Reports

41%Marked serious

0.0%Recovered

97%Died or euthanised

3 daysTypical onset

How soon it started

Same day

5 38%

1–2 days

1 7.7%

3–7 days

4 31%

1–4 weeks

2 15%

Over a month

1 7.7%

How the animals did

Still unwell when reported

1 3.1%

Died

31 97%

Problems reported at the same time

31 97%

11 34%

9 28%

8 25%

7 22%

6 19%

6 19%

5 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause cardiac arrest in cats?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Selamectin in cats · Medicines most reported with cardiac arrest