Application site reaction after Fipronil + S-methoprene (Frontline Plus) in cats
28 reports to the FDA describe application site reaction in cats given Fipronil + S-methoprene. That is 7.6% of all reports for this medicine, compared with 8.1% across reports for all cat medicines.
28Reports
32%Marked serious
18%Recovered
0.0%Died or euthanised
4 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause application site reaction in cats?
- 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 4 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Application site reaction with similar medicines
- Application site reaction after Spinosad (Comfortis) 25 reports · 0.2% of its reports
- Application site reaction after Nitenpyram (Capstar) 41 reports · 0.5% of its reports
- Application site reaction after Imidacloprid + Moxidectin (Advantage Multi) 1,047 reports · 13% of its reports
- Application site reaction after Flumethrin + Imidacloprid (Seresto) 187 reports · 28% of its reports
- Application site reaction after Imidacloprid + Pyriproxyfen 45 reports · 6.9% of its reports
All reported side effects of Fipronil + S-methoprene in cats · Medicines most reported with application site reaction