Restlessness or agitation after Butorphanol + Dexmedetomidine + Ketamine in cats

23 reports to the FDA describe restlessness or agitation in cats given Butorphanol + Dexmedetomidine + Ketamine. That is 18% of all reports for this medicine, compared with 4.9% across reports for all cat medicines, so it is reported unusually often with this medicine.

23Reports
22%Marked serious
48%Recovered
8.7%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
14 61%
1–2 days
6 26%
3–7 days
1 4.3%
1–4 weeks
1 4.3%
Over a month
1 4.3%

How the animals did

Recovered
11 48%
Still unwell when reported
6 26%
Died
2 8.7%
Not known
4 17%

Problems reported at the same time

Dilated pupils
9 39%
Behaviour change
8 35%
Not sleeping
8 35%
Dysphoria
6 26%
Loss of appetite
5 22%
Vocalising
3 13%
Lethargy
3 13%
Anxiety
3 13%

Age of the animals

Under 1 year
9
1–3 years
2
4–7 years
5
8–11 years
1
12+ years
3

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Questions owners ask

Can Butorphanol + Dexmedetomidine + Ketamine cause restlessness or agitation in cats?
23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Butorphanol + Dexmedetomidine + Ketamine in cats · Medicines most reported with restlessness or agitation