Behaviour change after Butorphanol + Dexmedetomidine + Ketamine in cats

The FDA has received 26 reports of behaviour change in cats after Butorphanol + Dexmedetomidine + Ketamine. That is 20% of all reports for this medicine, compared with 5.4% across reports for all cat medicines, so it is reported unusually often with this medicine.

26Reports

31%Marked serious

38%Recovered

12%Died or euthanised

Same dayTypical onset

How soon it started

Same day

14 54%

1–2 days

7 27%

3–7 days

2 7.7%

1–4 weeks

1 3.8%

Over a month

2 7.7%

How the animals did

Recovered

10 38%

Still unwell when reported

5 19%

Died

1 3.8%

Euthanised

2 7.7%

Not known

8 31%

Problems reported at the same time

Restlessness or agitation

8 31%

Dilated pupils

7 27%

Loss of appetite

5 19%

Itching

4 15%

Lethargy

4 15%

Vocalising

4 15%

Anxiety

3 12%

Not sleeping

3 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Questions owners ask

Can Butorphanol + Dexmedetomidine + Ketamine cause behaviour change in cats?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Buprenorphine 1,072 reports · 19% of its reports
Behaviour change after Dexmedetomidine (Dexdomitor) 222 reports · 8.5% of its reports

All reported side effects of Butorphanol + Dexmedetomidine + Ketamine in cats · Medicines most reported with behaviour change