Pancreatitis after Trazodone in dogs

The FDA has received 39 reports of pancreatitis in dogs after Trazodone. That is 1.5% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

39Reports

92%Marked serious

5.1%Recovered

44%Died or euthanised

25 daysTypical onset

How soon it started

Same day

1 3.3%

1–2 days

6 20%

3–7 days

1 3.3%

1–4 weeks

12 40%

Over a month

10 33%

How the animals did

Recovered

2 5.1%

Still unwell when reported

14 36%

Died

2 5.1%

Euthanised

15 38%

Not known

6 15%

Problems reported at the same time

26 67%

25 64%

21 54%

21 54%

18 46%

17 44%

Abnormal ultrasound finding

11 28%

Elevated amylase

11 28%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause pancreatitis in dogs?: 39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 25 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pancreatitis with similar medicines

Pancreatitis after Gabapentin 117 reports · 1.3% of its reports
Pancreatitis after Selegiline (Anipryl) 25 reports · 0.6% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with pancreatitis