Skin necrosis after Tigilanol Tiglate in dogs

54 reports to the FDA describe skin necrosis in dogs given Tigilanol Tiglate. That is 2.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports

94%Marked serious

28%Recovered

17%Died or euthanised

1 daysTypical onset

How soon it started

Same day

19 36%

1–2 days

15 28%

3–7 days

10 19%

1–4 weeks

5 9.4%

Over a month

4 7.5%

How the animals did

Recovered

15 28%

Still unwell when reported

3 5.6%

Died

5 9.3%

Euthanised

4 7.4%

Not known

27 50%

Problems reported at the same time

Injection site reaction

40 74%

40 74%

34 63%

29 54%

19 35%

19 35%

18 33%

Limb non-weight bearing

14 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tigilanol Tiglate cause skin necrosis in dogs?: 54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin necrosis with similar medicines

Skin necrosis after Diphenhydramine 24 reports · 0.5% of its reports
Skin necrosis after Butorphanol 28 reports · 0.6% of its reports

All reported side effects of Tigilanol Tiglate in dogs · Medicines most reported with skin necrosis