Mast cell tumour after Tigilanol Tiglate in dogs

The FDA has received 46 reports of mast cell tumour in dogs after Tigilanol Tiglate. That is 2.3% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

46Reports

61%Marked serious

13%Recovered

2.2%Died or euthanised

10 daysTypical onset

How soon it started

Same day

7 18%

1–2 days

5 13%

3–7 days

6 15%

1–4 weeks

11 28%

Over a month

11 28%

How the animals did

Recovered

3 6.5%

Recovered with lasting effects

3 6.5%

Still unwell when reported

6 13%

Euthanised

1 2.2%

Not known

33 72%

Problems reported at the same time

Didn't work as expected

36 78%

Injection site reaction

33 72%

28 61%

9 20%

9 20%

7 15%

7 15%

6 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tigilanol Tiglate cause mast cell tumour in dogs?: 46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Mast cell tumour with similar medicines

Mast cell tumour after Diphenhydramine 32 reports · 0.7% of its reports
Mast cell tumour after Butorphanol 24 reports · 0.5% of its reports
Mast cell tumour after Famotidine 26 reports · 1.0% of its reports

All reported side effects of Tigilanol Tiglate in dogs · Medicines most reported with mast cell tumour