Malaise after Pyrantel in dogs

The FDA has received 58 reports of malaise in dogs after Pyrantel. That is 1.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

58Reports

14%Marked serious

8.6%Recovered

40%Died or euthanised

Same dayTypical onset

How soon it started

Same day

12 67%

1–2 days

3 17%

3–7 days

2 11%

1–4 weeks

0 0.0%

Over a month

1 5.6%

How the animals did

Recovered

5 8.6%

Still unwell when reported

8 14%

Died

22 38%

Euthanised

1 1.7%

Not known

22 38%

Problems reported at the same time

23 40%

16 28%

14 24%

12 21%

6 10%

4 6.9%

Didn't work as expected

4 6.9%

Weight loss

4 6.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Pyrantel cause malaise in dogs?: 58 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

Malaise after Pyrantel + Sarolaner (Simparica Trio) 90 reports · 0.2% of its reports
Malaise after Fenbendazole 32 reports · 0.5% of its reports
Malaise after Praziquantel + Pyrantel 20 reports · 0.5% of its reports

All reported side effects of Pyrantel in dogs · Medicines most reported with malaise