Decreased heart rate after Propofol in dogs

The FDA has received 35 reports of decreased heart rate in dogs after Propofol. That is 1.1% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

35Reports

91%Marked serious

57%Recovered

29%Died or euthanised

Same dayTypical onset

How soon it started

Same day

32 94%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

1 2.9%

Over a month

1 2.9%

How the animals did

Recovered

20 57%

Still unwell when reported

4 11%

Died

8 23%

Euthanised

2 5.7%

Not known

1 2.9%

Problems reported at the same time

10 29%

7 20%

5 14%

5 14%

Decreased respiratory rate

4 11%

Vomiting

4 11%

Cyanosis

3 8.6%

Apnoea

3 8.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Propofol cause decreased heart rate in dogs?: 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased heart rate with similar medicines

Decreased heart rate after Butorphanol 47 reports · 1.1% of its reports
Decreased heart rate after Isoflurane 46 reports · 1.7% of its reports
Decreased heart rate after Atipamezole 27 reports · 1.0% of its reports
Decreased heart rate after Ketamine 20 reports · 1.1% of its reports

All reported side effects of Propofol in dogs · Medicines most reported with decreased heart rate