Elevated cholesterol (total) after Pimobendan (Vetmedin) in dogs

The FDA has received 28 reports of elevated cholesterol (total) in dogs after Pimobendan. That is 0.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

28Reports

50%Marked serious

0.0%Recovered

14%Died or euthanised

106 daysTypical onset

How soon it started

Same day

1 5.9%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

2 12%

Over a month

14 82%

How the animals did

Still unwell when reported

8 29%

Died

2 7.1%

Euthanised

2 7.1%

Not known

16 57%

Problems reported at the same time

Liver problems

24 86%

Elevated gamma-glutamyl transferase (ggt)

11 39%

10 36%

10 36%

6 21%

6 21%

5 18%

Abnormal ultrasound finding

5 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pimobendan treats heart failure and some heart disease.

Products with this ingredient include Vetmedin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pimobendan cause elevated cholesterol (total) in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 106 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pimobendan in dogs · Medicines most reported with elevated cholesterol (total)