Pr-lymph node(s), lesion(s) after Moxidectin (ProHeart 6) in dogs

40 reports to the FDA describe pr-lymph node(s), lesion(s) in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

40Reports
2.5%Marked serious
2.5%Recovered
65%Died or euthanised
–Typical onset
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How the animals did

Recovered
1 2.5%
Died
24 60%
Euthanised
2 5.0%
Not known
13 33%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
5
4–7 years
24
8–11 years
9
12+ years
2

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause pr-lymph node(s), lesion(s) in dogs?
40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Moxidectin in dogs · Medicines most reported with pr-lymph node(s), lesion(s)