Mucous stool after Moxidectin (ProHeart 6) in dogs

The FDA has received 81 reports of mucous stool in dogs after Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

81Reports

41%Marked serious

16%Recovered

9.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

21 45%

1–2 days

12 26%

3–7 days

4 8.5%

1–4 weeks

5 11%

Over a month

5 11%

How the animals did

Recovered

13 16%

Still unwell when reported

32 40%

Died

6 7.4%

Euthanised

2 2.5%

Not known

28 35%

Problems reported at the same time

55 68%

44 54%

27 33%

24 30%

23 28%

15 19%

13 16%

12 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause mucous stool in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Mucous stool with similar medicines

Mucous stool after Ivermectin + Pyrantel (Heartgard Plus) 258 reports · 0.2% of its reports
Mucous stool after Milbemycin Oxime + Spinosad (Trifexis) 180 reports · 0.1% of its reports
Mucous stool after Milbemycin Oxime + Praziquantel (Interceptor Plus) 91 reports · 0.3% of its reports
Mucous stool after Milbemycin Oxime (Interceptor) 82 reports · 0.3% of its reports
Mucous stool after Selamectin (Revolution) 41 reports · 0.1% of its reports
Mucous stool after Ivermectin (Heartgard) 27 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with mucous stool