Eosinophilia after Moxidectin (ProHeart 6) in dogs

79 reports to the FDA describe eosinophilia in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

79Reports

33%Marked serious

5.1%Recovered

14%Died or euthanised

3 daysTypical onset

How soon it started

Same day

11 26%

1–2 days

10 24%

3–7 days

5 12%

1–4 weeks

4 9.5%

Over a month

12 29%

How the animals did

Recovered

4 5.1%

Still unwell when reported

35 44%

Died

8 10%

Euthanised

3 3.8%

Not known

29 37%

Problems reported at the same time

30 38%

29 37%

28 35%

23 29%

16 20%

16 20%

16 20%

12 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause eosinophilia in dogs?: 79 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eosinophilia with similar medicines

Eosinophilia after Ivermectin + Pyrantel (Heartgard Plus) 132 reports · 0.1% of its reports
Eosinophilia after Milbemycin Oxime + Spinosad (Trifexis) 122 reports · 0.1% of its reports
Eosinophilia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 62 reports · 0.2% of its reports
Eosinophilia after Milbemycin Oxime (Interceptor) 39 reports · 0.1% of its reports
Eosinophilia after Selamectin (Revolution) 39 reports · 0.1% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with eosinophilia