Cardiac enlargement after Milbemycin Oxime (Interceptor) in dogs
27 reports to the FDA describe cardiac enlargement in dogs given Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
27Reports
44%Marked serious
7.4%Recovered
30%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).
Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime cause cardiac enlargement in dogs?
- 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Cardiac enlargement with similar medicines
- Cardiac enlargement after Ivermectin + Pyrantel (Heartgard Plus) 90 reports · 0.1% of its reports
- Cardiac enlargement after Milbemycin Oxime + Spinosad (Trifexis) 153 reports · 0.1% of its reports
- Cardiac enlargement after Moxidectin (ProHeart 6) 94 reports · 0.2% of its reports
- Cardiac enlargement after Milbemycin Oxime + Praziquantel (Interceptor Plus) 35 reports · 0.1% of its reports
- Cardiac enlargement after Selamectin (Revolution) 43 reports · 0.1% of its reports
All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with cardiac enlargement