Self trauma after Milbemycin Oxime + Spinosad (Trifexis) in dogs
259 reports to the FDA describe self trauma in dogs given Milbemycin Oxime + Spinosad. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Spinosad kills fleas; monthly chewable.
Products with this combination include Trifexis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime + Spinosad cause self trauma in dogs?
- 259 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 2 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Self trauma with similar medicines
- Self trauma after Ivermectin + Pyrantel (Heartgard Plus) 123 reports · 0.1% of its reports
- Self trauma after Milbemycin Oxime + Praziquantel (Interceptor Plus) 21 reports · 0.1% of its reports
- Self trauma after Selamectin (Revolution) 22 reports · 0.1% of its reports
All reported side effects of Milbemycin Oxime + Spinosad in dogs · Medicines most reported with self trauma