Not himself/herself after Milbemycin Oxime + Spinosad (Trifexis) in dogs

48 reports to the FDA describe not himself/herself in dogs given Milbemycin Oxime + Spinosad. That is 0.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

48Reports

19%Marked serious

31%Recovered

2.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

25 60%

1–2 days

9 21%

3–7 days

0 0.0%

1–4 weeks

1 2.4%

Over a month

7 17%

How the animals did

Recovered

15 31%

Still unwell when reported

16 33%

Died

1 2.1%

Not known

16 33%

Problems reported at the same time

26 54%

21 44%

13 27%

13 27%

9 19%

6 13%

6 13%

6 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Spinosad kills fleas; monthly chewable.

Products with this combination include Trifexis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Spinosad cause not himself/herself in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not himself/herself with similar medicines

Not himself/herself after Ivermectin + Pyrantel (Heartgard Plus) 91 reports · 0.1% of its reports
Not himself/herself after Moxidectin (ProHeart 6) 165 reports · 0.3% of its reports
Not himself/herself after Milbemycin Oxime + Praziquantel (Interceptor Plus) 100 reports · 0.3% of its reports
Not himself/herself after Selamectin (Revolution) 26 reports · 0.1% of its reports

All reported side effects of Milbemycin Oxime + Spinosad in dogs · Medicines most reported with not himself/herself