Flatulence after Milbemycin Oxime + Spinosad (Trifexis) in dogs

115 reports to the FDA describe flatulence in dogs given Milbemycin Oxime + Spinosad. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported less often than average with this medicine.

115Reports

34%Marked serious

46%Recovered

4.3%Died or euthanised

Same dayTypical onset

How soon it started

Same day

47 57%

1–2 days

7 8.4%

3–7 days

3 3.6%

1–4 weeks

2 2.4%

Over a month

24 29%

How the animals did

Recovered

43 37%

Recovered with lasting effects

10 8.7%

Still unwell when reported

17 15%

Died

3 2.6%

Euthanised

2 1.7%

Not known

40 35%

Problems reported at the same time

53 46%

51 44%

45 39%

42 37%

20 17%

Didn't work as expected

14 12%

Liver problems

12 10%

Itching

11 9.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Spinosad kills fleas; monthly chewable.

Products with this combination include Trifexis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Spinosad cause flatulence in dogs?: 115 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Flatulence with similar medicines

Flatulence after Ivermectin + Pyrantel (Heartgard Plus) 150 reports · 0.1% of its reports
Flatulence after Moxidectin (ProHeart 6) 29 reports · 0.1% of its reports
Flatulence after Milbemycin Oxime + Praziquantel (Interceptor Plus) 56 reports · 0.2% of its reports
Flatulence after Milbemycin Oxime (Interceptor) 59 reports · 0.2% of its reports
Flatulence after Selamectin (Revolution) 26 reports · 0.1% of its reports

All reported side effects of Milbemycin Oxime + Spinosad in dogs · Medicines most reported with flatulence