Dry mucous membrane after Milbemycin Oxime + Spinosad (Trifexis) in dogs
166 reports to the FDA describe dry mucous membrane in dogs given Milbemycin Oxime + Spinosad. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
166Reports
57%Marked serious
52%Recovered
11%Died or euthanised
1 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Spinosad kills fleas; monthly chewable.
Products with this combination include Trifexis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime + Spinosad cause dry mucous membrane in dogs?
- 166 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Dry mucous membrane with similar medicines
- Dry mucous membrane after Ivermectin + Pyrantel (Heartgard Plus) 63 reports · 0.0% of its reports
- Dry mucous membrane after Moxidectin (ProHeart 6) 126 reports · 0.2% of its reports
- Dry mucous membrane after Milbemycin Oxime + Praziquantel (Interceptor Plus) 34 reports · 0.1% of its reports
All reported side effects of Milbemycin Oxime + Spinosad in dogs · Medicines most reported with dry mucous membrane