Hyponatremia after Maropitant (Cerenia) in dogs

193 reports to the FDA describe hyponatremia in dogs given Maropitant. That is 1.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

193Reports

79%Marked serious

7.8%Recovered

50%Died or euthanised

2 daysTypical onset

How soon it started

Same day

49 31%

1–2 days

35 22%

3–7 days

28 18%

1–4 weeks

24 15%

Over a month

24 15%

How the animals did

Recovered

13 6.7%

Recovered with lasting effects

2 1.0%

Still unwell when reported

52 27%

Died

43 22%

Euthanised

54 28%

Not known

29 15%

Problems reported at the same time

134 69%

121 63%

112 58%

110 57%

109 56%

103 53%

97 50%

77 40%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Maropitant prevents vomiting and motion sickness.

Products with this ingredient include Cerenia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Maropitant cause hyponatremia in dogs?: 193 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyponatremia with similar medicines

Hyponatremia after Capromorelin (Entyce) 28 reports · 1.8% of its reports

All reported side effects of Maropitant in dogs · Medicines most reported with hyponatremia