Proprioception deficit after Ivermectin (Heartgard) in dogs
28 reports to the FDA describe proprioception deficit in dogs given Ivermectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.
28Reports
68%Marked serious
36%Recovered
25%Died or euthanised
18 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly).
Products with this ingredient include Heartgard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin cause proprioception deficit in dogs?
- 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 18 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Proprioception deficit with similar medicines
- Proprioception deficit after Ivermectin + Pyrantel (Heartgard Plus) 42 reports · 0.0% of its reports
- Proprioception deficit after Milbemycin Oxime + Spinosad (Trifexis) 124 reports · 0.1% of its reports
- Proprioception deficit after Moxidectin (ProHeart 6) 66 reports · 0.1% of its reports
- Proprioception deficit after Milbemycin Oxime + Praziquantel (Interceptor Plus) 24 reports · 0.1% of its reports
All reported side effects of Ivermectin in dogs · Medicines most reported with proprioception deficit