Breathing problems after Ivermectin (Heartgard) in dogs

345 reports to the FDA describe breathing problems in dogs given Ivermectin. That is 2.9% of all reports for this medicine, compared with 2.7% across reports for all dog medicines.

345Reports
51%Marked serious
28%Recovered
21%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
42 20%
1–2 days
21 10.0%
3–7 days
15 7.1%
1–4 weeks
26 12%
Over a month
107 51%

How the animals did

Recovered
74 21%
Recovered with lasting effects
22 6.4%
Still unwell when reported
78 23%
Died
40 12%
Euthanised
34 9.9%
Not known
97 28%

Problems reported at the same time

Age of the animals

Under 1 year
41
1–3 years
88
4–7 years
78
8–11 years
86
12+ years
42

About this medicine

Ivermectin prevents heartworm disease (monthly).

Products with this ingredient include Heartgard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin cause breathing problems in dogs?
345 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Ivermectin in dogs · Medicines most reported with breathing problems