Liver disorder after Ivermectin (Heartgard) in dogs
The FDA has received 20 reports of liver disorder in dogs after Ivermectin. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
20Reports
75%Marked serious
5.0%Recovered
35%Died or euthanised
–Typical onset
Sponsored
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly).
Products with this ingredient include Heartgard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin cause liver disorder in dogs?
- 20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Liver disorder with similar medicines
- Liver disorder after Ivermectin + Pyrantel (Heartgard Plus) 71 reports · 0.0% of its reports
- Liver disorder after Milbemycin Oxime + Spinosad (Trifexis) 177 reports · 0.1% of its reports
- Liver disorder after Moxidectin (ProHeart 6) 26 reports · 0.1% of its reports
- Liver disorder after Milbemycin Oxime + Praziquantel (Interceptor Plus) 24 reports · 0.1% of its reports
All reported side effects of Ivermectin in dogs · Medicines most reported with liver disorder