Arthritis after Ivermectin + Pyrantel (Heartgard Plus) in dogs
The FDA has received 70 reports of arthritis in dogs after Ivermectin + Pyrantel. That is 0.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.
Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Pyrantel cause arthritis in dogs?
- 70 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 26 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Arthritis with similar medicines
- Arthritis after Milbemycin Oxime + Spinosad (Trifexis) 370 reports · 0.3% of its reports
- Arthritis after Moxidectin (ProHeart 6) 36 reports · 0.1% of its reports
- Arthritis after Milbemycin Oxime + Praziquantel (Interceptor Plus) 149 reports · 0.5% of its reports
- Arthritis after Milbemycin Oxime (Interceptor) 46 reports · 0.2% of its reports
- Arthritis after Ivermectin (Heartgard) 20 reports · 0.2% of its reports
All reported side effects of Ivermectin + Pyrantel in dogs · Medicines most reported with arthritis