Increased percentage reticulocytes after Ilunocitinib (Zenrelia) in dogs

26 reports to the FDA describe increased percentage reticulocytes in dogs given Ilunocitinib. That is 1.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports
46%Marked serious
12%Recovered
15%Died or euthanised
85 daysTypical onset
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How soon it started

Same day
1 4.3%
1–2 days
1 4.3%
3–7 days
0 0.0%
1–4 weeks
1 4.3%
Over a month
20 87%

How the animals did

Recovered
3 12%
Still unwell when reported
13 50%
Euthanised
4 15%
Not known
6 23%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
4
4–7 years
15
8–11 years
5
12+ years
0

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause increased percentage reticulocytes in dogs?
26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 85 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Increased percentage reticulocytes with similar medicines

All reported side effects of Ilunocitinib in dogs · Medicines most reported with increased percentage reticulocytes