Decreased percentage of reticulocytes after Ilunocitinib (Zenrelia) in dogs

The FDA has received 59 reports of decreased percentage of reticulocytes in dogs after Ilunocitinib. That is 2.7% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

59Reports
44%Marked serious
17%Recovered
14%Died or euthanised
106 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
2 4.3%
3–7 days
1 2.2%
1–4 weeks
13 28%
Over a month
30 65%

How the animals did

Recovered
10 17%
Still unwell when reported
21 36%
Died
1 1.7%
Euthanised
7 12%
Not known
20 34%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
11
4–7 years
25
8–11 years
19
12+ years
3

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause decreased percentage of reticulocytes in dogs?
59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 106 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased percentage of reticulocytes with similar medicines

All reported side effects of Ilunocitinib in dogs · Medicines most reported with decreased percentage of reticulocytes