Hair coat discolouration after Fipronil + S-methoprene (Frontline Plus) in dogs
28 reports to the FDA describe hair coat discolouration in dogs given Fipronil + S-methoprene. That is 0.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.
28Reports
68%Marked serious
43%Recovered
0.0%Died or euthanised
10 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause hair coat discolouration in dogs?
- 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 10 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Hair coat discolouration with similar medicines
- Hair coat discolouration after Spinosad (Comfortis) 32 reports · 0.1% of its reports
- Hair coat discolouration after Imidacloprid + Moxidectin (Advantage Multi) 20 reports · 0.2% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with hair coat discolouration