Loss of appetite after Enrofloxacin + Silver Sulfadiazine in dogs

The FDA has received 21 reports of loss of appetite in dogs after Enrofloxacin + Silver Sulfadiazine. That is 10% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

21Reports
76%Marked serious
14%Recovered
9.5%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
3 16%
1–2 days
3 16%
3–7 days
2 11%
1–4 weeks
8 42%
Over a month
3 16%

How the animals did

Recovered
3 14%
Still unwell when reported
9 43%
Died
2 9.5%
Not known
7 33%

Problems reported at the same time

10 48%
Lethargy
8 38%
Wobbliness (ataxia)
7 33%
Liver problems
7 33%
Behaviour change
5 24%
Leucocytosis
5 24%
Neutrophilia
5 24%
Kidney problems
5 24%

Age of the animals

Under 1 year
2
1–3 years
1
4–7 years
8
8–11 years
7
12+ years
2

About this medicine

Enrofloxacin treats bacterial infections.

Questions owners ask

Can Enrofloxacin + Silver Sulfadiazine cause loss of appetite in dogs?
21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Enrofloxacin + Silver Sulfadiazine in dogs · Medicines most reported with loss of appetite