Cardiac enlargement after Enalapril in dogs

The FDA has received 21 reports of cardiac enlargement in dogs after Enalapril. That is 1.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

21Reports

90%Marked serious

14%Recovered

19%Died or euthanised

15 daysTypical onset

How soon it started

Same day

2 20%

1–2 days

3 30%

3–7 days

0 0.0%

1–4 weeks

2 20%

Over a month

3 30%

How the animals did

Recovered

1 4.8%

Recovered with lasting effects

2 9.5%

Still unwell when reported

8 38%

Died

2 9.5%

Euthanised

2 9.5%

Not known

6 29%

Problems reported at the same time

Abnormal radiograph finding

11 52%

10 48%

9 43%

7 33%

6 29%

4 19%

4 19%

4 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Enalapril cause cardiac enlargement in dogs?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cardiac enlargement with similar medicines

Cardiac enlargement after Melarsomine (Immiticide) 66 reports · 0.3% of its reports
Cardiac enlargement after Diphenhydramine 20 reports · 0.4% of its reports
Cardiac enlargement after Furosemide 39 reports · 2.6% of its reports

All reported side effects of Enalapril in dogs · Medicines most reported with cardiac enlargement