Not himself/herself after Afoxolaner (NexGard) in dogs

95 reports to the FDA describe not himself/herself in dogs given Afoxolaner. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

95Reports

35%Marked serious

39%Recovered

11%Died or euthanised

1 daysTypical onset

How soon it started

Same day

26 33%

1–2 days

16 21%

3–7 days

10 13%

1–4 weeks

14 18%

Over a month

12 15%

How the animals did

Recovered

37 39%

Still unwell when reported

13 14%

Died

4 4.2%

Euthanised

6 6.3%

Not known

35 37%

Problems reported at the same time

37 39%

34 36%

23 24%

22 23%

20 21%

14 15%

13 14%

12 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Afoxolaner kills fleas and ticks; given as a monthly chewable.

Products with this ingredient include NexGard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Afoxolaner cause not himself/herself in dogs?: 95 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not himself/herself with similar medicines

Not himself/herself after Fluralaner (Bravecto) 313 reports · 0.5% of its reports
Not himself/herself after Sarolaner (Simparica) 101 reports · 0.6% of its reports
Not himself/herself after Lotilaner (Credelio) 79 reports · 0.8% of its reports
Not himself/herself after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 58 reports · 0.6% of its reports
Not himself/herself after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 63 reports · 2.0% of its reports

All reported side effects of Afoxolaner in dogs · Medicines most reported with not himself/herself