Kidney problems after Acetylcysteine in dogs

The FDA has received 27 reports of kidney problems in dogs after Acetylcysteine. That is 44% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

27Reports

93%Marked serious

0.0%Recovered

56%Died or euthanised

1 daysTypical onset

How soon it started

Same day

9 35%

1–2 days

5 19%

3–7 days

0 0.0%

1–4 weeks

6 23%

Over a month

6 23%

How the animals did

Still unwell when reported

7 26%

Died

8 30%

Euthanised

7 26%

Not known

5 19%

Problems reported at the same time

25 93%

21 78%

15 56%

14 52%

13 48%

Abnormal ultrasound finding

11 41%

Leucocytosis

9 33%

Prolonged one stage prothrombin time (ospt)

8 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Acetylcysteine cause kidney problems in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Melarsomine (Immiticide) 434 reports · 1.9% of its reports
Kidney problems after Polysulfated Glycosaminoglycan 319 reports · 5.8% of its reports
Kidney problems after Diphenhydramine 221 reports · 4.7% of its reports
Kidney problems after Butorphanol 203 reports · 4.6% of its reports
Kidney problems after Cefpodoxime 248 reports · 6.1% of its reports
Kidney problems after Tramadol 441 reports · 12% of its reports
Kidney problems after Florfenicol + Mometasone + Terbinafine 52 reports · 1.5% of its reports
Kidney problems after Desoxycorticosterone Pivalate 253 reports · 7.6% of its reports
Kidney problems after Propofol 143 reports · 4.7% of its reports
Kidney problems after Dirlotapide 78 reports · 2.8% of its reports

All reported side effects of Acetylcysteine in dogs · Medicines most reported with kidney problems