Hyperexcitation after Tiletamine + Zolazepam in cats

The FDA has received 35 reports of hyperexcitation in cats after Tiletamine + Zolazepam. That is 2.1% of all reports for this medicine, compared with 0.2% across reports for all cat medicines, so it is reported unusually often with this medicine.

35Reports

11%Marked serious

14%Recovered

14%Died or euthanised

–Typical onset

How the animals did

Recovered

5 14%

Still unwell when reported

2 5.7%

Died

5 14%

Not known

23 66%

Problems reported at the same time

8 23%

7 20%

5 14%

4 11%

4 11%

Paddling

3 8.6%

Fever

3 8.6%

Restlessness or agitation

3 8.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause hyperexcitation in cats?: 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperexcitation with similar medicines

Hyperexcitation after Ketamine 66 reports · 2.0% of its reports
Hyperexcitation after Butorphanol 31 reports · 1.4% of its reports
Hyperexcitation after Propofol 27 reports · 2.3% of its reports

All reported side effects of Tiletamine + Zolazepam in cats · Medicines most reported with hyperexcitation