Didn't work as expected after Selamectin (Revolution) in cats
984 reports to the FDA describe didn't work as expected in cats given Selamectin. That is 4.5% of all reports for this medicine, compared with 8.7% across reports for all cat medicines, so it is reported less often than average with this medicine.
984Reports
5.8%Marked serious
2.2%Recovered
2.2%Died or euthanised
46 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).
Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Selamectin cause didn't work as expected in cats?
- 984 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 46 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Didn't work as expected with similar medicines
- Didn't work as expected after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) 59 reports · 1.8% of its reports
- Didn't work as expected after Milbemycin Oxime (Interceptor) 28 reports · 6.9% of its reports
All reported side effects of Selamectin in cats · Medicines most reported with didn't work as expected