Blood in stool after Selamectin (Revolution) in cats

The FDA has received 41 reports of blood in stool in cats after Selamectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all cat medicines.

41Reports
0.0%Marked serious
0.0%Recovered
7.3%Died or euthanised
–Typical onset
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How the animals did

Died
3 7.3%
Not known
38 93%

Problems reported at the same time

10 24%
10 24%
Mucous stool
4 9.8%
3 7.3%

Age of the animals

Under 1 year
13
1–3 years
9
4–7 years
5
8–11 years
7
12+ years
3

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause blood in stool in cats?
41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Selamectin in cats · Medicines most reported with blood in stool